Satisfaction in Social Roles and Physical Function in Immune-mediated Inflammatory Diseases: A Cross-Sectional Study

Rocco Spagnuolo; Francesco Salvatore Iaquinta; Daniele Mauro; Ilenia Pantano; Stefano Dastoli; Saverio Naty; Cristina Cosco; Rosellina Margherita Mancina; Daniela Iacono; Emanuela Gaggiano; Annarita Ruggiero; Steven Paul Nisticò; Francesco Ciccia; Rosa Daniela Grembiale; Doldo Patrizia

doi:10.2174/1574887117666220531162104

Satisfaction in Social Roles and Physical Function in Immune-mediated Inflammatory Diseases: A Cross-Sectional Study

Rev Recent Clin Trials. 2022 May 31. doi: 10.2174/1574887117666220531162104. Online ahead of print.

Authors

Affiliations

¹ Department of Clinical and Experimental Medicine, Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy.
² Department of Health Sciences Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy.
³ Dipartimento di Medicina di Precisione, Università della Campania L. Vanvitelli, Naples, Italy.
⁴ Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden.
⁵ Department of Health Sciences Magna Graecia University of Catanzaro, Calabria, Catanzaro.

PMID: 35642115
DOI: 10.2174/1574887117666220531162104

Abstract

Background: Although mood disorders have been well characterized in Immune-mediated inflammatory diseases, physical function and satisfaction in social roles have not yet been defined as independent domains.

Objective: The study aims to assess satisfaction in social roles and physical function alterations in an Immune-mediated inflammatory diseases population and identify associated characteristics.

Methods: Physical function and social roles satisfaction were evaluated through the Patient-Reported Outcomes Measurement System. Besides comparisons between groups, univariate and multivariable logistic regression were performed to identify independent predictors.

Results: Two hundred sixty-five Immune-mediated Inflammatory Diseases patients and 206 controls were recruited. Compared with controls, Inflammatory Bowel Diseases patients had impaired physical function (p<0.001), while Inflammatory Arthritis patients reported impairment in both domains (p<0.001, each). In the univariate logistic regression, gender, high school educational level, physical activity and occupation were positively associated with physical function and social role satisfaction (p<0.001; p=0.001; p<0.001; p=0.001 and p<0.001; p=0.012; p=0.008; p=0.004, respectively). Active disease and steroids were inversely associated with physical function and social roles satisfaction (p=0.033; p=0.022 and p=0.002; p=0.038, respectively). Further associations were found between age and physical function (p=0.002); biological treatment and ESR with social roles satisfaction (p<0.001; p=0.043; respectively). In the multivariable regression, gender remained associated with physical function (p<0.001) and social roles satisfaction (p=0.003). Negatively associated factors were biological treatment for satisfaction in social roles (p<0.001) and steroids for physical function (p=0.021) and social roles satisfaction (p=0.018).

Conclusion: Immune-mediated Inflammatory diseases determine alterations in physical function and social life satisfaction. Gender and treatment are independent associated factors. Patient-Reported Outcomes should be considered in clinical management to define patients' real needs.

Keywords: Immune-mediated inflammatory diseases; Inflammatory Arthritis; Inflammatory Bowel Disease; PROMIS; Physical Function; Psoriasis; Social Satisfaction..