Nowadays, about 14% of couples have difficulty in conceiving, and half of the cases are attributed to men. Asthenozoospermia or poor sperm motility is considered as the cause of infertility in males which is most common. Even though energy metabolism is considered the main reason for the etiology of asthenospermia, few attempts are made to determine the pathway of its metabolic potential. Recognition of cellular as well as molecular pathways that lead to reduced sperm motility may lead to the implementation of new therapeutic strategies to eliminate low sperm motility in people with asthenozoospermia. This review article discusses the key causes of decreased sperm motility and some of the muted genes and metabolic causes of the same.
Keywords: ATP production; Asthenozoospermia; Autophagy; Curcumin; Glycolysis; Male infertility; OXPHOS; ROS; cAMP/PRKA pathway.
© 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG.