3D Co-doped Ni-based conductive MOFs modified electrochemical sensor for highly sensitive detection of l-tryptophan

Wei Huang; Yao Chen; Lingyan Wu; Mei Long; Zhifeng Lin; Qianqian Su; Fuli Zheng; Siying Wu; Huangyuan Li; Guangxia Yu

doi:10.1016/j.talanta.2022.123596

3D Co-doped Ni-based conductive MOFs modified electrochemical sensor for highly sensitive detection of l-tryptophan

Talanta. 2022 Sep 1:247:123596. doi: 10.1016/j.talanta.2022.123596. Epub 2022 May 27.

Authors

Wei Huang¹, Yao Chen², Lingyan Wu², Mei Long³, Zhifeng Lin⁴, Qianqian Su², Fuli Zheng², Siying Wu⁴, Huangyuan Li⁵, Guangxia Yu⁶

Affiliations

¹ College of Chemical and Biological Engineering, Guangxi Normal University for Nationalities, China.
² Fujian Key Lab of Environmental Factors and Cancer, Key Lab of Environment and Health, Department of Preventive Medicine, School of Public Health, Fujian Medical University, China.
³ Department of Cardiology, ZiBo Central Hospital, Zibo, China.
⁴ Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, China.
⁵ Fujian Key Lab of Environmental Factors and Cancer, Key Lab of Environment and Health, Department of Preventive Medicine, School of Public Health, Fujian Medical University, China. Electronic address: lhy@fjmu.edu.cn.
⁶ Fujian Key Lab of Environmental Factors and Cancer, Key Lab of Environment and Health, Department of Preventive Medicine, School of Public Health, Fujian Medical University, China. Electronic address: Guangxiayu@fjmu.edu.cn.

PMID: 35640476
DOI: 10.1016/j.talanta.2022.123596

Abstract

L-tryptophan (Trp) is an essential amino acid for humans and plays crucial roles in many metabolic functions. Trp levels can be used for diagnosing different kinds of metabolic disorders and the symptoms associated with those diseases. Herein, a novel, simple and sensitive sensor based on 3D peony-like bimetallic conductive MOFs (Co-Ni-MOFs) was fabricated for the electrochemical determination of Trp. The bimetallic conductive MOFs were synthesized by a facile one-pot hydrothermal process. On account of the synergy between the Ni²⁺ and Co²⁺ ions, the bimetallic Co-Ni-MOFs showed excellent electrochemical performance, including good conductivity, large effective surface areas, and high electrocatalytic reactivity toward the oxidation of Trp. Consequently, the Co-Ni-MOFs-modified electrodes obtained a wide linear range from 10 nmol L^-1 to 300 μmol L^-1 and a low detection limit of 8.7 nmol L^-1 (S/N = 3) for Trp. Additionally, the prepared sensor also displayed high selectivity, long-term stability and reproducibility. Moreover, the proposed sensor was successfully applied to determine the levels of Trp in the plasma of mice after cadmium intoxication.

Keywords: Electrochemical; Metal-organic frameworks; Sensor; l-tryptophan.

MeSH terms

Animals
Electrochemical Techniques*
Electrodes
Limit of Detection
Mice
Reproducibility of Results
Tryptophan* / chemistry

Substances

Tryptophan