<b>Background and Objective:</b> Cadmium is a heavy metal that has a wide range of applications in human existence. Cadmium may bind to the protein metallothionein and decrease kidney function once it enters the body. The purpose of this study was to investigate the renal protective activity of TVLE against CdCl<sub>2</sub>-induced renal toxicity in rats. <b>Materials and Methods:</b> TVLE was prepared and characterized using instrumental analysis and spectral data. Furthermore, the IC<sub>50</sub> of TVLE against the Vero renal carcinoma cell line was calculated. Adult albino rats were used to assess the renal protective activity of TVLE (150 and 300 mg kg<sup>1</sup> b.wt.) in CdCl<sub>2</sub>-treated rats. <b>Results:</b> IC<sub>50 </sub>of TVLE against Vero cell line equals 148.25 μg mL<sup>1</sup>. The daily oral administration of TVLE at concentrations of 150 and 300 mg kg<sup>1</sup> b.wt. for 21 days to CdCl<sub>2</sub>-treated rates resulted in a significant improvement in tumour volume and tumour weight, urea, creatinine, uric acid, TNF-α, NOx, TBARs, GSH, CAT, SOD, GPx and VEGF-C gene expression in CdCl<sub>2</sub>-treated rats. Furthermore, TVLE almost normalized these effects in renal histoarchitecture. <b>Conclusion:</b> The biochemical, histological and MRI examinations of the current study suggested that TVLE have renal protective activity against CdCl<sub>2</sub>-induced renal toxicity in rats.
Keywords: TVLE; VEGF-C gene expression and anticancer; anti-angiogenic; cadmium; renal carcinoma cell line.