MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types

Front Biosci (Landmark Ed). 2022 May 23;27(5):167. doi: 10.31083/j.fbl2705167.

Abstract

The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.

Keywords: Dark Kinome; Illuminating the Druggable Genome; MAP kinases; MAP3K; MAPK; cancer; understudied kinase.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Humans
  • MAP Kinase Signaling System*
  • Mitogen-Activated Protein Kinases / genetics
  • Mitogen-Activated Protein Kinases / metabolism
  • Neoplasms* / genetics
  • Phosphorylation
  • Signal Transduction / genetics

Substances

  • Mitogen-Activated Protein Kinases