A state-of-the-art review on the recent advances of niosomes as a targeted drug delivery system

Int J Pharm. 2022 Aug 25:624:121878. doi: 10.1016/j.ijpharm.2022.121878. Epub 2022 May 28.

Abstract

The buildup of nonionic surfactants in the aqueous environment produces niosomes. The usage of niosomes is becoming increasingly frequent due to their sustainability, low cost of components and assembly, large-scale manufacture, and, finally, easy maintenance of the niosomes to the other. Because of their nonionic characteristics, niosomes play a critical role in medication delivery systems. Controlled release and targeted distribution of niosomes to treat cancer, infectious illnesses, and other disorders are one of their most important properties. Niosomes can also be injected by ocular and transdermal routes, which are less common than oral and parenteral administration. Using niosomes to manufacture biotechnology goods and novel vaccines is one of the most exciting research fields today. The molecular structure of niosomes, the physicochemical characteristics of nonionic surfactants in their formulation, the influence of external stimuli on niosomes, the many methods of niosomes administration, and their diverse therapeutic qualities are all explored in this study.

Keywords: Drug delivery; Nanoparticles; Niosomes; Nonionic surfactants; Routes of administrations.

Publication types

  • Review

MeSH terms

  • Administration, Cutaneous
  • Drug Delivery Systems / methods
  • Liposomes* / chemistry
  • Surface-Active Agents / chemistry
  • Vaccines*

Substances

  • Liposomes
  • Surface-Active Agents
  • Vaccines