Scalp Stimulation Targets for Neurological Conditions-Evidence from Large-Scale Meta-Analyses

J Integr Neurosci. 2022 Apr 15;21(3):83. doi: 10.31083/j.jin2103083.

Abstract

Background: Neurological disorders are a major source of suffering for patients worldwide. Scalp stimulation methods have been widely applied in treating a number of neurological disorders. Recently, our understanding of pathological mechanisms associated with neurological disorders has been enhanced significantly. Nevertheless, these findings have yet to be well-integrated into scalp stimulation treatments for neurological disorders.

Methods: In a previous study, we proposed new brain targets for scalp stimulation in the treatment of eight common mental disorders based on the results of a large-scale meta-analyses using Neurosynth. This study aims to extend our previous findings in identifying surface brain targets for seven common neurological disorders: Alzheimer's disease, aphasia, chronic pain, dementia, dyslexia, mild cognitive impairment, and Parkinson's disease, utilizing a similar method.

Results: We hidentified seven to eight potential scalp stimulation targets for each disorder and used both 10-20 EEG system and acupuncture points to locate these targets to facilitate its clinical application.

Conclusions: The proposed target protocols may facilitate and extend clinical applications of scalp stimulation methods such as transcranial electrical stimulation and scalp acupuncture in the treatment of neurological disorders.

Keywords: brain stimulation transcranial electrical stimulation; meta-analysis; neurological disorder; scalp acupuncture; scalp stimulation.

MeSH terms

  • Acupuncture Therapy*
  • Cognitive Dysfunction* / therapy
  • Humans
  • Nervous System Diseases* / therapy
  • Scalp
  • Transcranial Direct Current Stimulation*