Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

Dahlia N Amato; Douglas V Amato; Olga V Mavrodi; William B Martin; Sarah N Swilley; Keith H Parsons; Dmitri V Mavrodi; Derek L Patton

doi:10.1021/acsmacrolett.7b00009

Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

ACS Macro Lett. 2017 Feb 21;6(2):171-175. doi: 10.1021/acsmacrolett.7b00009. Epub 2017 Feb 6.

Authors

Dahlia N Amato¹, Douglas V Amato², Olga V Mavrodi², William B Martin², Sarah N Swilley², Keith H Parsons², Dmitri V Mavrodi², Derek L Patton²

Affiliations

¹ School of Polymers and High Performance Materials and §Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.
² School of Polymers and High Performance Materials and Department of Biological Sciences, The University of Southern Mississippi, Hattiesburg, Mississippi 39406, United States.

PMID: 35632888
DOI: 10.1021/acsmacrolett.7b00009

Abstract

We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAs derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAs enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.