Microwave-Assisted Post-Ugi Reactions for the Synthesis of Polycycles

Liangliang Song; Lingchao Cai; Erik V Van der Eycken

doi:10.3390/molecules27103105

Microwave-Assisted Post-Ugi Reactions for the Synthesis of Polycycles

Molecules. 2022 May 12;27(10):3105. doi: 10.3390/molecules27103105.

Authors

Liangliang Song¹, Lingchao Cai¹, Erik V Van der Eycken^{2

3}

Affiliations

¹ Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China.
² Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001 Leuven, Belgium.
³ Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia.

Abstract

Microwave irradiation and post-Ugi reactions own their respective advantages in comparison with other strategies. The combination of microwave irradiation and post-Ugi reactions shows paramount importance in the construction of polycycles. This minireview outlines the recent developments of microwave-assisted post-Ugi reactions for the synthesis of polycycles. Through transition metal-catalyzed or transition metal-free transformations, diverse polycycles are prepared in an efficient, rapid, and step-economical manner.

Keywords: copper; microwave; palladium; polycycles; post-Ugi.

Publication types

Review

MeSH terms

Microwaves*

Grants and funding

This research was funded by FWO [Fund for Scientific Research-Flanders (Belgium)], the Research Council of the KU Leuven and “RUDN University Strategic Academic Leadership Program”.