This Special Issue, entitled "Personalized Medicine for Liver Disease: From Molecular Mechanisms to Potential Targeted Therapies", includes 11 publications from colleagues working on various liver diseases including non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), hepatocellular carcinoma (HCC), primary biliary cholangitis (PBC), as well as various treatment modalities including pharmacotherapies and liver transplantation [...].