Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Magdalena Dzitkowska-Zabielska; Aleksandra Bojarczuk; Małgorzata Borczyk; Marcin Piechota; Michał Korostyński; Jakub Grzegorz Adamczyk; Grzegorz Trybek; Myosotis Massidda; Paweł Cięszczyk

doi:10.3390/genes13050870

Transmission Distortion of MCT1 rs1049434 among Polish Elite Athletes

Genes (Basel). 2022 May 12;13(5):870. doi: 10.3390/genes13050870.

Authors

Magdalena Dzitkowska-Zabielska¹, Aleksandra Bojarczuk¹, Małgorzata Borczyk², Marcin Piechota², Michał Korostyński², Jakub Grzegorz Adamczyk³, Grzegorz Trybek⁴, Myosotis Massidda⁵, Paweł Cięszczyk¹

Affiliations

¹ Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
² Laboratory of Pharmacogenomics, Department of Molecular Pharmacology, Maj Institute of Pharmacology Polish Academy of Sciences, 31-343 Krakow, Poland.
³ Department of Theory of Sport, Józef Piłsudski University of Physical Education, 00-968 Warsaw, Poland.
⁴ Department of Oral Surgery, Pomeranian Medical University, 70-111 Szczecin, Poland.
⁵ Department of Life and Environmental Sciences, University of Cagliari, 72-09124 Cagliari, Italy.

Abstract

Background: To date, nearly 300 genetic markers were linked to endurance and power/strength traits. The current study aimed to compare genotype distributions and allele frequencies of the common polymorphisms: MCT1 rs1049434, NRF2 rs12594956, MYBPC3 rs1052373 and HFE rs1799945 in Polish elite athletes versus nonathletes.

Methods: The study involved 101 male elite Polish athletes and 41 healthy individuals from the Polish population as a control group. SNP data were extracted from whole-genome sequencing (WGS) performed using the following parameters: paired reads of 150 bps, at least 90 Gb of data per sample with 300 M reads and 30× mean coverage.

Results: All the analyzed polymorphisms conformed to Hardy-Weinberg equilibrium (HWE) in athletes and the control group, except the MCT1 rs1049434, where allele T was over-represented in the elite trainers' group. No significant between-group differences were found for analyzed polymorphisms.

Conclusions: The MCT1 rs1049434 transmission distortion might be characteristic of Polish athletes and the effect of strict inclusion criteria. This result and the lack of statistically significant changes in the frequency of other polymorphisms between the groups might result from the small group size.

Keywords: HWE; athletes; endurance; polymorphisms; speed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Athletes*
Case-Control Studies
Gene Frequency
Genotype
Humans
Male
Monocarboxylic Acid Transporters* / genetics
Poland
Polymorphism, Single Nucleotide*
Symporters* / genetics

Substances

Monocarboxylic Acid Transporters
Symporters
monocarboxylate transport protein 1

Grants and funding

This work was supported by the grants of the Ministry of Science and Higher Education in 2018–2022 “Searching for new genes conditioning the predisposition to perform certain types of physical effort” (2017/27/B/NZ7/00204). Computational resources for this research were supplied by PL-Grid Infrastructure.