PSMA-Positive Follicular Thyroid Carcinoma Incidentally Detected by [68Ga]Ga-PSMA-11 PET/CT: Correlation with Immunohistology Confirms Neovascular PSMA-Expression

Florian Rosar; Caroline Burgard; Christian Neubert; Phillip R Stahl; Fadi Khreish; Samer Ezziddin

doi:10.3390/diagnostics12051211

PSMA-Positive Follicular Thyroid Carcinoma Incidentally Detected by [⁶⁸Ga]Ga-PSMA-11 PET/CT: Correlation with Immunohistology Confirms Neovascular PSMA-Expression

Diagnostics (Basel). 2022 May 12;12(5):1211. doi: 10.3390/diagnostics12051211.

Authors

Florian Rosar¹, Caroline Burgard¹, Christian Neubert², Phillip R Stahl³, Fadi Khreish¹, Samer Ezziddin¹

Affiliations

¹ Department of Nuclear Medicine, Saarland University, 66421 Homburg, Germany.
² Department of Otorhinolaryngology, Head and Neck Surgery, Saarland University, 66421 Homburg, Germany.
³ Department of Pathology, Saarland University, 66421 Homburg, Germany.

Abstract

We present an interesting image of an intense PSMA-positive follicular thyroid carcinoma incidentally detected by [⁶⁸Ga]Ga-PSMA-11 PET/CT in a 76-year-old man with biochemical recurrence of prostate cancer. Immunohistochemical staining demonstrated PSMA expression in the endothelial cells of tumor tissue. This interesting image should remind colleagues to consider malignant thyroid neoplasia in PSMA-positive thyroid lesions.

Keywords: PET/CT; PSMA; follicular thyroid cancer.

Grants and funding

This research received no external funding.