Breast cancer needs to be detected early to reduce mortality rate. Ultrasound imaging (US) could significantly enhance diagnosing cases with dense breasts. Most of the existing computer-aided diagnosis (CAD) systems employ a single ultrasound image for the breast tumor to extract features to classify it as benign or malignant. However, the accuracy of such CAD system is limited due to the large tumor size and shape variation, irregular and ambiguous tumor boundaries, and low signal-to-noise ratio in ultrasound images due to their noisy nature and the significant similarity between normal and abnormal tissues. To handle these issues, we propose a deep-learning-based radiomics method based on breast US sequences in this paper. The proposed approach involves three main components: radiomic features extraction based on a deep learning network, so-called ConvNeXt, a malignancy score pooling mechanism, and visual interpretations. Specifically, we employ the ConvNeXt network, a deep convolutional neural network (CNN) trained using the vision transformer style. We also propose an efficient pooling mechanism to fuse the malignancy scores of each breast US sequence frame based on image-quality statistics. The ablation study and experimental results demonstrate that our method achieves competitive results compared to other CNN-based methods.
Keywords: CAD system; breast cancer; deep learning; transformers; ultrasound sequence.