Household cooking oil type and risk of oral micronucleus frequency in Chinese nonsmokers

Jia-Jun Jing; Li-E Zhang; Wen-Min Lu; Yang Peng; Liang Wang; Shao-Hui Liu; Ming-Jun Wang; Song-Feng Ou; Jie Yang; Yun-Feng Zou

doi:10.1016/j.envpol.2022.119520

Household cooking oil type and risk of oral micronucleus frequency in Chinese nonsmokers

Environ Pollut. 2022 Aug 15:307:119520. doi: 10.1016/j.envpol.2022.119520. Epub 2022 May 25.

Authors

Jia-Jun Jing¹, Li-E Zhang², Wen-Min Lu¹, Yang Peng², Liang Wang³, Shao-Hui Liu¹, Ming-Jun Wang⁴, Song-Feng Ou¹, Jie Yang¹, Yun-Feng Zou⁵

Affiliations

¹ Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China.
² Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China; Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, 530021, China.
³ Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Waco, TX, 76798, USA.
⁴ Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China.
⁵ Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, 530021, China; Guangxi Colleges and Universities Key Laboratory of Prevention and Control of Highly Prevalent Diseases, Guangxi Medical University, Nanning, 530021, China; Guangxi Key Laboratory of Environment and Health Research, Guangxi Medical University, Nanning, 530021, China. Electronic address: zouyunfeng@gxmu.edu.cn.

PMID: 35623571
DOI: 10.1016/j.envpol.2022.119520

Abstract

Household animal fat has been linked to increased incidence of cancers compared with vegetable fat. However, few epidemiological studies have associated these two cooking oil types with precancerous genotoxic effects, such as occurrence of micronuclei (MN). This study aimed to explore the association between oral MN frequency and household cooking oil type and whether the association can be attributed to polycyclic aromatic hydrocarbons (PAHs). We collected information about individual cooking oil use, measured genotoxic effects by MN tests and urinary PAHs metabolites (OHPAHs) in 245 nonsmokers. The associations between household cooking oil type and MN frequency and OHPAHs were analyzed using generalized linear models (GLMs) and logistic regression models, evaluating odds ratios and coefficient (95% confidence intervals) (ORs, 95% Cls; β, 95% Cls). The odds of animal fat consumers, rather than vegetable fat consumers, was positively associated with higher MN frequency (OR = 1.94, P < 0.05). The associations were discovered in participants only using kitchen ventilation (OR = 2.04, P < 0.05). Animal fat consumers had higher total OHPAHs than vegetable fat consumers (1.58 ± 0.22 mg/mol, Cr vs 1.20 ± 0.12 mg/mol, Cr; P = 0.028). Significant correlations were observed between total OHPAHs quartiles and increased MN frequency (β = 0.38, P-trend = 0.026). After stratifying by household cooking oil type, sensitivity analyses showed that the positive association between total OHPAHs quartiles and increased MN frequency was only observed in animal fat consumers (β = 0.61, P-trend = 0.030). In conclusion, usage of household animal fat was associated with an increased odds of oral MN frequency in Chinese nonsmokers and the odds correlated with increased PAHs exposure. This finding supplemented evidence associating cooking oil type with genotoxic effects and explained its association with PAHs exposure.

Keywords: Animal fat; Cooking oil; Micronucleus frequency; Nonsmokers; Polycyclic aromatic hydrocarbons; Vegetable fat.

MeSH terms

China
Cooking
Humans
Non-Smokers*
Polycyclic Aromatic Hydrocarbons* / analysis
Ventilation

Substances

Polycyclic Aromatic Hydrocarbons