Peculiarities of Humoral Immunity Formation in Medical Institution Employees Recovered from or Vaccinated against COVID-19 in Irkutsk

V I Dubrovina; D D Bryukhova; N O Kiseleva; M V Chesnokova; K M Korytov; A B Pyatidesyatnikova; V A Vishnyakov; S V Balakhonov

doi:10.1007/s10517-022-05492-5

Peculiarities of Humoral Immunity Formation in Medical Institution Employees Recovered from or Vaccinated against COVID-19 in Irkutsk

Bull Exp Biol Med. 2022 May;173(1):54-58. doi: 10.1007/s10517-022-05492-5. Epub 2022 May 27.

Authors

V I Dubrovina¹, D D Bryukhova², N O Kiseleva², M V Chesnokova², K M Korytov², A B Pyatidesyatnikova², V A Vishnyakov², S V Balakhonov²

Affiliations

¹ Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia. dubrovina-valya@mail.ru.
² Irkutsk Antiplague Research Institute, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Irkutsk, Russia.

Abstract

We performed a seroepidemiological survey of the level and structure of population immunity to SARS-CoV-2 among employees of medical institution in the Irkutsk region during the COVID-19 pandemic. Seroprevalence assessment was organized from May 2020 to April 2021. The level of antibodies to SARS-CoV-2 was measured by ELISA. It was found that 139 (46%) of 299 examined workers were seropositive, including 50 (36%) vaccinated against COVID-19, 75 (54%) patients diagnosed with COVID-19, and 14 (10%) asymptomatic cases of SARS-CoV-2. The results obtained should be taken into account when predicting the dynamics of the epidemic process and organizing preventive (antiepidemic) measures, including vaccination.

Keywords: COVID-19; SARS-CoV-2; humoral immunity; seroprevalence; specific antibodies.

MeSH terms

Antibodies, Viral
COVID-19* / epidemiology
COVID-19* / prevention & control
Humans
Immunity, Humoral
Pandemics / prevention & control
SARS-CoV-2
Seroepidemiologic Studies

Substances

Antibodies, Viral