Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries

O V Stepanova; A D Voronova; A V Chadin; G A Fursa; E K Karsuntseva; M P Valikhov; A S Semkina; I V Reshetov; V P Chekhonin

doi:10.1007/s10517-022-05504-4

Neurotrophin-3 Enhances the Effectiveness of Cell Therapy in Chronic Spinal Cord Injuries

Bull Exp Biol Med. 2022 May;173(1):114-118. doi: 10.1007/s10517-022-05504-4. Epub 2022 May 27.

Authors

O V Stepanova^{1

2}, A D Voronova³, A V Chadin³, G A Fursa^{3

4}, E K Karsuntseva³, M P Valikhov^{3

5}, A S Semkina^{3

6}, I V Reshetov⁷, V P Chekhonin^{3

6}

Affiliations

¹ V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia. sms-34@yandex.ru.
² National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia. sms-34@yandex.ru.
³ V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
⁴ M. V. Lomonosov Moscow State University, Moscow, Russia.
⁵ National Medical Research Center of Cardiology, Ministry of Health of the Russian Federation, Moscow, Russia.
⁶ Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
⁷ University Clinical Hospital No. 1, I. M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia.

PMID: 35622252
DOI: 10.1007/s10517-022-05504-4

Abstract

Neurotrophin-3 enhances the effectiveness of human olfactory ensheathing cells in improving hind limb mobility in rats with post-traumatic cysts of the spinal cord. Transplantation of olfactory ensheathing cells into spinal cord cysts reduced their size; neurotrophin-3 did not modulate this effect. Combined preparation of human olfactory ensheathing cells and neurotrophin- 3 can be used in neurosurgery for the treatment of patients with spinal cord injuries.

Keywords: cell therapy; human olfactory ensheathing cells; neurotrophin-3; olfactory mucosa; spinal cord injury.

MeSH terms

Animals
Cell Transplantation
Cell- and Tissue-Based Therapy*
Cysts* / therapy
Humans
Nerve Growth Factors / genetics
Nerve Regeneration
Neurotrophin 3* / pharmacology
Rats
Spinal Cord
Spinal Cord Injuries* / therapy

Substances

NTF3 protein, human
Nerve Growth Factors
Neurotrophin 3