A pitfall in hemoglobin A1c measurement with high performance liquid chromatography method in the diagnosis of onset of fulminant type 1 diabetes mellitus

Yasuharu Oe; Takatoshi Anno; Yukari Katsuhara; Ryo Sugahara; Miki Kobayashi; Mieko Yakusue; Masayo Tamura; Yukiko Kimura; Fumiko Kawasaki; Kohei Kaku; Hideaki Kaneto; Akira Kitanaka

doi:10.1111/jdi.13834

A pitfall in hemoglobin A1c measurement with high performance liquid chromatography method in the diagnosis of onset of fulminant type 1 diabetes mellitus

J Diabetes Investig. 2022 Nov;13(11):1943-1944. doi: 10.1111/jdi.13834. Epub 2022 May 27.

Authors

Affiliations

¹ Department of Clinical Laboratory, Kawasaki Medical School General Medical Center, Okayama, Japan.
² Department of General Internal Medicine 1, Kawasaki Medical School, Okayama, Japan.
³ Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
⁴ Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki, Japan.

Abstract

We showed a case with the onset of fulminant type 1 diabetes mellitus (FT1DM) whose HbA1c could not be measured with HPLC method. We think that the reason why his HbA1c was not be detected was associated with the presence of labile hemoglobin A1c (LHbA1c). These result mean that it is possible that LHbA1c can bring about a pitfall on HPLC method in diagnosis of onset of FT1DM.

Publication types

Letter

MeSH terms

Chromatography, High Pressure Liquid
Diabetes Mellitus, Type 1* / diagnosis
Diagnosis, Differential
Glycated Hemoglobin / analysis
Humans

Substances

Glycated Hemoglobin A