Filling Defect of Ipsilateral Transverse Sinus in Acute Large Artery Occlusion

Yi Chen; Sheng Zhang; Shenqiang Yan; Meixia Zhang; Ruiting Zhang; Feina Shi; David S Liebeskind; Mark Parsons; Min Lou

doi:10.3389/fneur.2022.863460

Filling Defect of Ipsilateral Transverse Sinus in Acute Large Artery Occlusion

Front Neurol. 2022 May 10:13:863460. doi: 10.3389/fneur.2022.863460. eCollection 2022.

Authors

Yi Chen¹, Sheng Zhang², Shenqiang Yan¹, Meixia Zhang³, Ruiting Zhang⁴, Feina Shi¹, David S Liebeskind⁵, Mark Parsons⁶, Min Lou¹

Affiliations

¹ Department of Neurology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
² Department of Neurology, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
³ Department of Neurology, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, China.
⁴ Department of Radiology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
⁵ UCLA Stroke Center, University of California, Los Angeles, Los Angeles, CA, United States.
⁶ Department of Neurology, John Hunter Hospital, University of Newcastle, New Lambton Heights, NSW, Australia.

Abstract

Background and purpose: Cerebral venous systems play a key role in regulating stroke outcomes. We aimed to elucidate the effect of the transverse sinus (TS) filling patterns on edema expansion and neurological outcomes in patients with acute large artery occlusion (LAO).

Materials and methods: We recruited consecutive patients with acute M1 middle cerebral artery and/or internal carotid artery occlusion who underwent pretreatment computed tomographic perfusion (CTP). On the reconstructed 4-dimensional computed tomographic angiography derived from CTP, the filling defect of the ipsilateral transverse sinus (FDITS) was defined as the length of contrast filling defect occupying at least half of the ipsilateral TS. An unfavorable outcome was defined as having a modified Rankin Scale (mRS) score of 3-6 at 3 months.

Results: A total of 318 patients were enrolled in the final analysis and 70 (22.0%) patients had baseline FDITS. The presence of FDITS was associated with the baseline NIHSS (odds ratio [OR] 1.119; 95% CI, 1.051-1.192; p < 0.001) and poor arterial collaterals (OR 3.665; 95% CI 1.730-7.766; p = 0.001). In addition, FDITS was associated with 24-h brain edema expansion (OR 7.188; 95% CI, 3.095-16.696; p < 0.001) and 3-month unfavorable outcome (OR 8.143; 95% CI 2.547-26.041; p < 0.001) independent of arterial collateral status. In the subgroup analysis of patients with FDITS who received reperfusion therapy, no significant difference was found in the rate of edema expansion and unfavorable outcome between non-reperfusion and reperfusion subgroups (both p > 0.05).

Conclusion: Filling defect of the ipsilateral transverse sinus was associated with edema expansion and an unfavorable outcome irrespective of the baseline arterial collateral status in patients with acute LAO, indicating that FDITS may be an important stroke-related prognostic imaging marker.

Keywords: brain edema; computer tomography; large artery occlusion in anterior circulation; reperfusion therapy; transverse sinus.