Relationship between Postoperative Intraocular Pressure and Refractive Outcomes in Patients after Deep Anterior Lamellar Keratoplasty

Dayna Yong Wei Wei; Liang Shen; Ray Manotosh; Anna Tan Wee Tien; Charmaine Chai Hui-Chen

doi:10.4103/joco.joco_211_21

Relationship between Postoperative Intraocular Pressure and Refractive Outcomes in Patients after Deep Anterior Lamellar Keratoplasty

J Curr Ophthalmol. 2022 Apr 16;34(1):30-36. doi: 10.4103/joco.joco_211_21. eCollection 2022 Jan-Mar.

Authors

Dayna Yong Wei Wei¹, Liang Shen², Ray Manotosh^{1

3}, Anna Tan Wee Tien¹, Charmaine Chai Hui-Chen^{1

3}

Affiliations

¹ Department of Ophthalmology, National University Hospital, National University Health System, Singapore.
² Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
³ Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Abstract

Purpose: To study the effect of intraocular pressure (IOP) on refractive outcomes after deep anterior lamellar keratoplasty (DALK).

Methods: This retrospective study included eyes which underwent DALK. DALK technique involved either modified Anwar big-bubble if possible or manual anterior lamellar dissection. Our main outcome measures are postoperative IOP and refractive outcomes at postoperative week and months 1, 3, 6, and 12.

Results: Fifty-nine eyes of 59 patients were included. DALK was performed for optical (93.2%) and tectonic (6.8%) purposes. 76.3% of the patients had keratoconus. Anwar's big-bubble technique was successful in 30 cases. Linear mixed-model was used to analyze the effect of the highest postoperative IOP measured prior to measurement of postoperative cylinder. Patients with greater maximum postoperative IOP measured had worse postoperative cylinder (P = 0.015) and spherical equivalent (P = 0.012). Those with IOP more than 21 mmHg had worse postoperative cylinder (P = 0.050) and spherical equivalent (P = 0.054). The method of DALK and presence of suture removal were not shown to statistically affect postoperative cylinder.

Conclusion: Our study shows a positive correlation between postoperative IOP and worse spherical equivalent and cylinder post-DALK, emphasizing the need for good IOP control with IOP-lowering medication(s).

Keywords: Big-bubble; Deep anterior lamellar keratoplasty; Intraocular pressure; Refractive outcomes.