PROTAC mediated FKBP12 degradation enhances Hepcidin expression via BMP signaling without immunosuppression activity

Affiliations

• ¹ MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, P. R. China.
• ² MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China.
• ³ Institute for Immunology and School of Medicine, Tsinghua University, Beijing, 100084, China.
• ⁴ MOE Key Laboratory of Protein Sciences, School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, 100084, China. yrao@mail.tsinghua.edu.cn.
• ⁵ MOE Key Laboratory of Protein Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, 100084, P. R. China. wwu@mail.tsinghua.edu.cn.