A single dose of recombinant VSV-RABVG vaccine provides full protection against RABV challenge

A single dose of recombinant VSV-RABV_G vaccine provides full protection against RABV challenge

Virol Sin. 2022 Jun;37(3):455-458. doi: 10.1016/j.virs.2022.02.008. Epub 2022 Feb 25.

¹ Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China.
² State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China.
³ Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China. Electronic address: sdxiong@suda.edu.cn.
⁴ State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; Key Laboratory of Preventive Veterinary Medicine of Hubei Province, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China. Electronic address: zling604@yahoo.com.
⁵ Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China. Electronic address: chunshengdong@suda.edu.cn.

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A replication-competent recombinant VSV with RABV-G protein replacement was generated.
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Single dose of VSV-RABV_G immunization induces potent anti-RABV_G immune response, including viral neutralizing antibodies.
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Mice intranasally immunized with single dose of VSV-RABV_G were 100% protected upon RABV challenge.