Traditional Chinese Medicine Constitution Discrimination Model Based on Metabolomics and Random Forest Decision Tree Algorithm

Chaodong Huang; Yufeng Chen; Bingtao Li; Qiyun Zhang; Li Jiang; Bin Nie; Lihua Chen; Hui Jian; Guoliang Xu

doi:10.1155/2022/3490130

Traditional Chinese Medicine Constitution Discrimination Model Based on Metabolomics and Random Forest Decision Tree Algorithm

Evid Based Complement Alternat Med. 2022 May 16:2022:3490130. doi: 10.1155/2022/3490130. eCollection 2022.

Authors

Chaodong Huang¹, Yufeng Chen², Bingtao Li^{1

3}, Qiyun Zhang^{1

3}, Li Jiang^{1

3}, Bin Nie², Lihua Chen⁴, Hui Jian⁵, Guoliang Xu^{1

3

6}

Affiliations

¹ Research Center of Differentiation and Development of Basic Theory of TCM, Jiangxi University of Chinese Medicine, Nanchang, China.
² School of Computer Science, Jiangxi University of Chinese Medicine, Nanchang, China.
³ Jiangxi Provincial Key Laboratory of Etiological Biology of Traditional Chinese Medicine, Nanchang, China.
⁴ Jiangxi University of Chinese Medicine Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Nanchang, China.
⁵ School of Basic Medicine, Jiangxi University of Chinese Medicine, Nanchang, China.
⁶ Jiangxi Provincial Key Laboratory of Traditional Chinese Medicine Pharmacology, Nanchang, China.

Abstract

Constitution refers to the comprehensive and relatively stable characteristics of the genetic or acquired morphological structure, physiological function, and psychological state in the process of human individual life. A special metabolomics data processing method is established to find the unique m/z value of each constitution. Combined with the random forest decision tree algorithm, the discrimination model of 9 constitutions in traditional Chinese medicine is constructed, and the model is verified and tested. The test results show that the classification accuracy of each constitution is higher than 80%, indicating that the model can well identify nine constitutions of traditional Chinese medicine. The classification accuracy is related to the difficulty of distinguishing between constitutions. In a word, this study provides a fast and accurate method to distinguish the constitution of traditional Chinese medicine, provides an objective representation for the classification and judgment of clinical constitution of traditional Chinese medicine, and provides a scientific basis for the modernization of traditional Chinese medicine.