COVID-19 Vaccination Willingness Among People Living With HIV in Wuhan, China

Songjie Wu; Fangzhao Ming; Zhongyuan Xing; Zhiyue Zhang; Shanhui Zhu; Wei Guo; Shi Zou; Jinli Liu; Yang Liu; Ke Liang

doi:10.3389/fpubh.2022.883453

COVID-19 Vaccination Willingness Among People Living With HIV in Wuhan, China

Front Public Health. 2022 May 9:10:883453. doi: 10.3389/fpubh.2022.883453. eCollection 2022.

Authors

Songjie Wu^{1

2}, Fangzhao Ming³, Zhongyuan Xing⁴, Zhiyue Zhang⁴, Shanhui Zhu⁵, Wei Guo^{6

7}, Shi Zou⁸, Jinli Liu⁸, Yang Liu^{9

10}, Ke Liang^{1

2

8

11}

Affiliations

¹ Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China.
² Hubei Engineering Center for Infectious Disease Prevention, Control and Treatment, Wuhan, China.
³ Wuchang District Center for Disease Control and Prevention, Wuhan, China.
⁴ School of Basic Medical Sciences, Wuhan University, Wuhan, China.
⁵ Medical Department, Zhongnan Hospital of Wuhan University, Wuhan, China.
⁶ Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China.
⁷ Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
⁸ Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
⁹ Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
¹⁰ School of Economics and Management, Wuhan University, Wuhan, China.
¹¹ Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China.

Abstract

Vaccination is essential to controlling the pandemic of coronavirus disease 2019 (COVID-19). People living with HIV (PLWH) were considered more vulnerable to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection compared with the general population. Therefore, it is urgent to protect PLWH from SARS-CoV-2 infection. For PLWH, vaccine hesitancy could be more common and may compromise vaccine coverage. Our study aimed to investigate the willingness to receive the COVID-19 vaccination among PLWH and associated factors. A cross-sectional online survey was performed among PLWH and the general population from 4 April to 18 April 2021 in Wuhan, China. The multivariable logistic regression was used to analyze associated factors for COVID-19 vaccination willingness among PLWH. A total of 556 PLWH and 570 individuals from the general population were enrolled. The COVID-19 vaccine willingness among PLWH was 60.8%, which was relatively lower than that in the general population (80.9%) (P < 0.001). The results of multivariable analysis indicated that PLWH with comorbidities (OR = 2.07, 95% CI: 1.25-3.45), those who had idea about PLWH would be more serious if they were infected with SARS-CoV-2 (OR = 1.67, 95% CI: 1.11-2.51) and those who thought their antiretroviral therapy (ART) would be affected by COVID-19 epidemic (OR = 2.04, 95% CI: 1.22-3.42) had higher willingness to receive COVID-19 vaccination. PLWH who had a monthly income over 5,000 RMB (OR = 0.64, 95% CI: 0.45-0.92) and had a sex orientation as non-homosexual (OR = 0.67, 95% CI: 0.47-0.96) were associated with lower willingness for COVID-19 vaccination. Our findings showed that the PLWH had a lower willingness for COVID-19 vaccination compared with the general population in Wuhan. Targeted interventions such as health education should be conducted to increase the willingness for COVID-19 vaccination among PLWH, thus enhancing COVID-19 vaccine uptake among PLWH.

Keywords: COVID-19 vaccination; PLWH; Wuhan; general population; willingness.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 Vaccines
COVID-19* / epidemiology
COVID-19* / prevention & control
China / epidemiology
Cross-Sectional Studies
HIV Infections* / complications
HIV Infections* / epidemiology
Humans
Pandemics
SARS-CoV-2
Vaccination

Substances

COVID-19 Vaccines