Early suspicion can save lives; mucormycosis in two children with diabetic ketoacidosis in Pakistan

J Pak Med Assoc. 2022 Apr;72(4):790-792. doi: 10.47391/JPMA.1659.

Abstract

Mucormycosis is a cause of fulminant necrotising fungal infection in children with underlying immunocompromising conditions. Rhino-orbito-cerebral infection is its most common form in the paediatric group with uncontrolled diabetes mellitus or diabetic ketoacidosis. The initial presentation can mimic a bacterial infection; thus a high index of suspicion is needed for timely intervention to reduce morbidity and mortality. We have presented a case of rhino-orbito-cerebral mucormycosis (ROCM) in two patients with diabetic ketoacidosis for the first time from Pakistan. Both the patients couldnot survive due to extensive disease on late presentation.

Keywords: Mucormycosis, Rhino-orbito-cerebral mucormycosis, Diabetic ketoacidosis, Diabetes mellitus, Pediatric, Children..

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use
  • Child
  • Diabetes Mellitus* / drug therapy
  • Diabetic Ketoacidosis* / diagnosis
  • Diabetic Ketoacidosis* / therapy
  • Humans
  • Mucormycosis* / complications
  • Mucormycosis* / diagnosis
  • Mucormycosis* / therapy
  • Orbital Diseases* / drug therapy
  • Orbital Diseases* / microbiology
  • Pakistan

Substances

  • Antifungal Agents