Aggregation-Induced Emission (AIE) Photosensitizer Combined Polydopamine Nanomaterials for Organelle-Targeting Photodynamic and Photothermal Therapy by the Recognition of Sialic Acid

Adv Healthc Mater. 2022 Aug;11(15):e2200242. doi: 10.1002/adhm.202200242. Epub 2022 Jun 9.

Abstract

The construction of organelle-targeting nanomaterials is an effective way to improve tumor imaging and treatment. Here, a new type of composite nanomaterial named as PTTPB is developed. PTTPB is composed of organelle-targeting aggregation-induced emission photosensitizer TTPB and polydopamine nanomaterials. With the functional modification of TTPB, PTTPB can recognize sialic acid on the cell membrane and present mitochondrial targeted capabilities. The intake of PTTPB in cancerous cells can be increased by the recognition process of cell membrane. PTTPB can generate singlet oxygen for photodynamic therapy (PDT), and present good photothermal conversion ability with irradiation. The PTTPB with organelle-targeting imaging-guided can realize the tumor ablation with the synergistic effect of PDT and photothermal therapy.

Keywords: organelle targeting; photodynamic therapy; photothermal therapy; sialic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Indoles
  • Mice
  • Mice, Inbred BALB C
  • Mitochondria
  • N-Acetylneuraminic Acid / therapeutic use
  • Nanostructures*
  • Neoplasms* / drug therapy
  • Photochemotherapy* / methods
  • Photosensitizing Agents / pharmacology
  • Photosensitizing Agents / therapeutic use
  • Photothermal Therapy
  • Polymers

Substances

  • Indoles
  • Photosensitizing Agents
  • Polymers
  • polydopamine
  • N-Acetylneuraminic Acid