Caffeine ingestion increases endurance performance of trained male cyclists when riding against a virtual opponent without altering muscle fatigue

Eur J Appl Physiol. 2022 Aug;122(8):1915-1928. doi: 10.1007/s00421-022-04969-5. Epub 2022 May 25.

Abstract

Purpose: Caffeine improves cycling time trial (TT) performance; however, it is unknown whether caffeine is ergogenic when competing against other riders. The aim of this study was to investigate whether caffeine improves performance during a 4-km cycling TT when riding against a virtual opponent, and whether it is associated with increased muscle activation and at the expense of greater end-exercise central and peripheral fatigue.

Methods: Using a randomized, crossover, and double-blind design, eleven well-trained cyclists completed a 4-km cycling TT alone without supplementation (CON), or against a virtual opponent after ingestion of placebo (OP-PLA) or caffeine (5 mg.kg-1, OP-CAF). Central and peripheral fatigue were quantified via the pre- to post-exercise decrease in voluntary activation and potentiated twitch force, respectively. Muscle activation was continually measured during the trial via electromyography activity.

Results: Compared to CON, OP-PLA improved 4-km cycling TT performance (P = 0.018), and OP-CAF further improved performance when compared to OP-PLA (P = 0.050). Muscle activation was higher in OP-PLA and OP-CAF than in CON throughout the trial (P = 0.003). The pre- to post-exercise reductions in voluntary activation and potentiated twitch force were, however, similar between experimental conditions (P > 0.05). Compared to CON, OP-PLA increased the rating of perceived exertion during the first 2 km, but caffeine blunted this increase with no difference between the OP-CAF and CON conditions.

Conclusions: Caffeine is ergogenic when riding against a virtual opponent, but this is not due to greater muscle activation or at the expense of greater end-exercise central or peripheral fatigue.

Keywords: Ergogenic aid; Head-to-head; Muscle activation; Muscle fatigue; Nutritional supplementation; Perceived exertion.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Athletic Performance* / physiology
  • Bicycling / physiology
  • Caffeine / pharmacology
  • Cross-Over Studies
  • Double-Blind Method
  • Eating
  • Humans
  • Male
  • Muscle Fatigue
  • Performance-Enhancing Substances* / pharmacology
  • Polyesters

Substances

  • Performance-Enhancing Substances
  • Polyesters
  • Caffeine