Nail-Patella Syndrome: Optical Coherence Tomography Angiography Findings

Hafsa Z Zuberi; Ashika Angirekula; Muhammad R Akram; Karanjit S Kooner

doi:10.1159/000523984

Nail-Patella Syndrome: Optical Coherence Tomography Angiography Findings

Case Rep Ophthalmol. 2022 Mar 29;13(1):227-233. doi: 10.1159/000523984. eCollection 2022 Jan-Apr.

Authors

Hafsa Z Zuberi¹, Ashika Angirekula¹, Muhammad R Akram¹, Karanjit S Kooner^{1

2}

Affiliations

¹ Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Department of Ophthalmology, Veteran Affairs North Texas Health Care System Medical Center, Dallas, Dallas, Texas, USA.

Abstract

We describe a 51-year-old Hispanic female with nail-patella syndrome (NPS), a rare genetic disease with a wide range of systemic features such as nail dysplasia and finger abnormalities, elbow webbing, iliac horn, patellar subluxation, and proteinuria. Some patients additionally have a history of glaucoma and other ocular features such as thick central corneal thickness, Lester's sign, prominent iris processes, and optic nerve cupping. Our patient had a history of glaucoma suspicion, prominent iris processes, increased cup to disc ratios, tilted optic discs, and tigroid fundi. In addition, we report optical coherence tomography angiography (OCTA) findings of focal areas of poor vessel densities in the macular and circumpapillary regions of both eyes, suggesting early compromised vascular supplies to these areas. Our OCTA findings (which include both structural and vascular details of retina and optic nerve) lend support to the use of this technology in patients with NPS.

Keywords: Glaucoma; Nail-patella syndrome; Ocular hypertension; Optical coherence tomography angiography.

Publication types

Case Reports