A new day for human challenge trials?

Abie Rohrig; Nir Eyal

doi:10.1016/j.molmed.2022.05.002

A new day for human challenge trials?

Trends Mol Med. 2022 Jul;28(7):531-532. doi: 10.1016/j.molmed.2022.05.002. Epub 2022 May 22.

Authors

Abie Rohrig¹, Nir Eyal²

Affiliations

¹ Swarthmore College, New York, NY, USA.
² Center for Population-Level Bioethics, Rutgers University, New Brunswick, NJ, USA. Electronic address: neyal@cplb.rutgers.edu.

Abstract

Two years into the coronavirus disease 2019 (COVID-19) pandemic and following several hot debates, the world's first COVID-19 human challenge trial has recently been published by Killingley et al. We review its findings and explain why this particular juncture in time makes additional challenge trials for COVID-19 and for other diseases justified and important.

Keywords: COVID-19; controlled human infection model; human challenge trials; research ethics; vaccine ethics.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

COVID-19*
Humans
Pandemics
SARS-CoV-2