Rhodium(II)-Catalyzed C(sp3 )-H Diamination of Arylcyclobutanes

Xinyu Liu; Zhifan Wang; Qiwei Wang; Yuanhua Wang

doi:10.1002/anie.202205493

Rhodium(II)-Catalyzed C(sp³ )-H Diamination of Arylcyclobutanes

Angew Chem Int Ed Engl. 2022 Jul 25;61(30):e202205493. doi: 10.1002/anie.202205493. Epub 2022 Jun 13.

Authors

Xinyu Liu^{1

2}, Zhifan Wang³, Qiwei Wang^{1

4}, Yuanhua Wang³

Affiliations

¹ Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041, China.
² University of Chinese Academy of Sciences, Beijing, 100049, China.
³ College of Chemistry, Sichuan University, Chengdu, 610041, China.
⁴ Department of Chemistry, Xihua University, Chengdu, 610039, China.

PMID: 35606340
DOI: 10.1002/anie.202205493

Abstract

Activated by multiple consecutive oxidative radical-polar crossover and desaturation processes, the selective diamination of arylcyclobutanes, which is difficult to perform by classical metallonitrene C-H insertion, was achieved in a short time by rhodium(II) catalysis using N-fluorobenzenesulfonimide (NFSI) as the oxidant and nitrogen source.

Keywords: Amination; Cyclobutanes; C−H Functionalization; Hydrogen Atom Transfer; Rhodium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Catalysis
Nitrogen
Oxidation-Reduction
Rhodium*

Substances

Rhodium
Nitrogen