HATs meet structural biology

Josep Rullo-Tubau; Paola Bartoccioni; Oscar Llorca; Ekaitz Errasti-Murugarren; Manuel Palacín

doi:10.1016/j.sbi.2022.102389

HATs meet structural biology

Curr Opin Struct Biol. 2022 Jun:74:102389. doi: 10.1016/j.sbi.2022.102389. Epub 2022 May 20.

Authors

Josep Rullo-Tubau¹, Paola Bartoccioni², Oscar Llorca³, Ekaitz Errasti-Murugarren⁴, Manuel Palacín⁵

Affiliations

¹ Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac 10, E-08028, Barcelona, Spain.
² Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac 10, E-08028, Barcelona, Spain; The Spanish CIBER of Rare Diseases (CIBERER), ISCIII. U-731, E-08028, Barcelona, Spain.
³ Structural Biology Programme, Spanish National Cancer Research Centre (CNIO), Melchor Fernández Almagro 3, E-28029, Madrid, Spain. Electronic address: https://twitter.com/OscarLlorcaCNIO.
⁴ Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac 10, E-08028, Barcelona, Spain; The Spanish CIBER of Rare Diseases (CIBERER), ISCIII. U-731, E-08028, Barcelona, Spain; Department of Physiological Sciences II, School of Medicine, University of Barcelona, Feixa Llarga (without number), E-08907, L'Hospitalet de Llobregat, Spain.
⁵ Institute for Research in Biomedicine, The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac 10, E-08028, Barcelona, Spain; The Spanish CIBER of Rare Diseases (CIBERER), ISCIII. U-731, E-08028, Barcelona, Spain; Department of Biochemistry and Molecular Biomedicine, Universitat de Barcelona, Spain. Electronic address: Manuel.palacin@irbbarcelona.org.

PMID: 35605357
DOI: 10.1016/j.sbi.2022.102389

Abstract

Heteromeric amino acid transporters (HATs) are one of the ten types of amino acid transporters present in the human body. Growing interest in the pathophysiological role of this group of transporters in rare and complex diseases and cancer has brought about the recent resolution of various structures of human HATs and bacterial homologues at atomic level. This knowledge sheds light on the mechanisms of transport used by these molecules. Here, we discuss the molecular bases underlying substrate specificity, binding asymmetry, and the impact of disease-causing mutations on transporter biogenesis and function.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Transport Systems* / chemistry
Amino Acid Transport Systems* / genetics
Amino Acid Transport Systems* / metabolism
Biological Transport / physiology
Humans
Molecular Biology*
Substrate Specificity

Substances

Amino Acid Transport Systems