Copper-catalyzed C-3 benzylation of quinoxalin-2(1 H)-ones with benzylsulfonyl hydrazides

Org Biomol Chem. 2022 Jun 8;20(22):4518-4521. doi: 10.1039/d2ob00744d.

Abstract

An unprecedented use of benzylsulfonyl hydrazides as benzylating agents has been demonstrated in the direct C-3 benzylation of quinoxalin-2(1H)-ones. A range of benzylsulfonyl hydrazides participated in the C-3 benzylation of quinoxalin-2(1H)-ones with CuCN as the catalyst and DTBP as the oxidant, delivering structurally diverse 3-benzylquinoxalin-2(1H)-ones in moderate to good yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Copper*
  • Hydrazines
  • Molecular Structure
  • Quinoxalines*

Substances

  • Hydrazines
  • Quinoxalines
  • Copper