Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes

Qiyou Ding; Zezheng Gao; Keyu Chen; Qiqi Zhang; Shiwan Hu; Linhua Zhao

doi:10.3389/fimmu.2022.883410

Inflammation-Related Epigenetic Modification: The Bridge Between Immune and Metabolism in Type 2 Diabetes

Front Immunol. 2022 May 6:13:883410. doi: 10.3389/fimmu.2022.883410. eCollection 2022.

Authors

Qiyou Ding^{1

2

3}, Zezheng Gao^{1

2}, Keyu Chen^{1

2

3}, Qiqi Zhang^{1

2}, Shiwan Hu^{1

2

3}, Linhua Zhao²

Affiliations

¹ Department of Endocrinology, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
² Institute of Metabolic Diseases, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
³ Graduate School, Beijing University of Chinese Medicine, Beijing, China.

Abstract

T2DM, as a typical metabolic inflammatory disease, is under the joint regulation of environmental factors and genetics, combining with a variety of epigenetic changes. Apart from epigenetic changes of islet β cells and glycometabolic tissues or organs, the inflammation-related epigenetics is also the core pathomechanism leading to β-cell dysfunction and insulin resistance. In this review, we focus on the epigenetic modification of immune cells' proliferation, recruitment, differentiation and function, providing an overview of the key genes which regulated by DNA methylation, histone modifications, and non-coding RNA in the respect of T2DM. Meanwhile, we further summarize the present situation of T2DM epigenetic research and elucidate its prospect in T2DM clinical diagnosis and treatment.

Keywords: DNA methylation; histone modifications; inflammation; macrophages; non-coding RNA; type 2 diabetes mellitus (T2DM).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

DNA Methylation
Diabetes Mellitus, Type 2*
Epigenesis, Genetic
Epigenomics
Humans
Inflammation / genetics
Inflammation / metabolism