Efficacy of Raman Spectroscopy in the Diagnosis of Uterine Cervical Neoplasms: A Meta-Analysis

Abstract

Background: Uterine cervical neoplasms is widely concerned due to its high incidence rate. Early diagnosis is extremely important for prognosis. The purpose of this article is evaluating the efficacy of Raman spectroscopy in the diagnosis of suspected uterine cervical neoplasms.

Methods: We searched PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of science up to September 1, 2021. By analyzing the true positive (TP), false positive (FP), true negative (TN) and false negative (FN) of six included study, we evaluated the pooled and grouping sensitivity, specificity, positive, and negative likelihood ratios (LR), and diagnostic odds ratio (DOR), with 95% confidence intervals (CI), based on random effects models. The overall diagnostic accuracy of Raman spectrum was evaluated by SROC curve analysis and AUC.

Results: After screening with inclusion and exclusion criteria, a total of six study were included in the study. The pooled sensitivity and specificity was 0.98 (95% Cl, 0.93-0.99) and 0.95 (95% Cl, 0.89-0.98). The total PLR and NLR were 21.05 (95% CI, 8.23-53.86) and 0.03 (95% CI, 0.01-0.07), respectively. And the AUC of the SROC curve which show the overall diagnostic accuracy was 0.99 (0.98-1.00).

Conclusion: Through analysis, we confirmed the role of Raman spectroscopy (RS) in the diagnosis of suspected uterine cervical tumors.

Systematic review registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42021284966].

Keywords: Raman spectroscopy; diagnostic efficacy; meta-analysis; translational medicine; uterine cervical tumors.