Historical Perspective: How the Discovery of HPV Virus Led to the Utilization of a Robot

Grégoire B Morand; Khalil Sultanem; Marco A Mascarella; Michael P Hier; Alex M Mlynarek

doi:10.3389/froh.2022.912861

Historical Perspective: How the Discovery of HPV Virus Led to the Utilization of a Robot

Front Oral Health. 2022 May 6:3:912861. doi: 10.3389/froh.2022.912861. eCollection 2022.

Authors

Grégoire B Morand¹, Khalil Sultanem², Marco A Mascarella¹, Michael P Hier¹, Alex M Mlynarek¹

Affiliations

¹ Department of Otolaryngology Head and Neck Surgery, Centre Intégré Universitaire de Santé et de Services Sociaux West-Central Montreal-Jewish General Hospital, McGill University, Montreal, QC, Canada.
² Department of Radiation Oncology, Centre Intégré Universitaire de Santé et de Services Sociaux West-Central Montreal-Jewish General Hospital, McGill University, Montreal, QC, Canada.

Abstract

The treatment of oropharyngeal cancer has undergone many paradigms shifts in recent decades. First considered a surgical disease, improvements in radiotherapy led to its popularization in the 1990s. Subsequently, the discovery of the human papillomavirus (HPV) in the pathogenesis of oropharyngeal cancer, as well as the increase in HPV-associated oropharynx cancer incidence, have prompted a reevaluation of its management. Its sensitivity to standard treatment with a favorable prognosis compared to non HPV-associated oropharyngeal cancer led to a focus on minimizing treatment toxicity. Advances in radiation and surgical techniques, including the use of transoral robotic surgery, gave the rationale to ongoing de-escalation clinical trials in HPV-associated oropharynx cancer.

Keywords: intensity-modulated; oropharyngeal neoplasms; quality of life; radiotherapy; xerostomia.