Catalyst-free decarboxylation of 4-hydroxycinnamic acids: efficient synthesis of 4-vinylphenols

Qian Yang; Youjuan Li; Huanhuan Liu; Enhua Wang; Mei Peng; Tingfei Deng; Xiong Pan; Zhongsheng Luo; Yanfang Yan; Lishou Yang; Xiaosheng Yang

doi:10.1098/rsos.220014

Catalyst-free decarboxylation of 4-hydroxycinnamic acids: efficient synthesis of 4-vinylphenols

R Soc Open Sci. 2022 Apr 27;9(4):220014. doi: 10.1098/rsos.220014. eCollection 2022 Apr.

Authors

Qian Yang¹, Youjuan Li^{2

3}, Huanhuan Liu^{2

3}, Enhua Wang¹, Mei Peng^{2

3}, Tingfei Deng^{2

3}, Xiong Pan^{2

3}, Zhongsheng Luo^{2

3}, Yanfang Yan^{2

3}, Lishou Yang^{2

3}, Xiaosheng Yang^{2

3}

Affiliations

¹ Department of Medicine and Food, Guizhou Vocational College of Agriculture, Guiyang 550041, People's Republic of China.
² State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, People's Republic of China.
³ The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550014, People's Republic of China.

Abstract

We report herein an efficient protocol for the synthesis of 4-vinylphenols by a catalyst-free decarboxylation of trans-4-hydroxycinnamic acids. A variety of 4-vinylphenols has been synthesized in moderate to excellent yields. This protocol also features no polymerization.

Keywords: 4-hydroxycinnamic acids; 4-vinylphenols; catalyst-free; decarboxylation.

Associated data

figshare/10.6084/m9.figshare.c.5953384