Isoquinoline alkaloids from the Corydalis tomentella with potential anti-hepatoma and antibacterial activities

Kaicheng Du; Yaxuan Liu; Kunqi Zong; Yumeng Wang; Jiaheng Li; Dali Meng

doi:10.1016/j.phytochem.2022.113240

Isoquinoline alkaloids from the Corydalis tomentella with potential anti-hepatoma and antibacterial activities

Phytochemistry. 2022 Aug:200:113240. doi: 10.1016/j.phytochem.2022.113240. Epub 2022 May 19.

Authors

Kaicheng Du¹, Yaxuan Liu¹, Kunqi Zong¹, Yumeng Wang¹, Jiaheng Li¹, Dali Meng²

Affiliations

¹ School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China.
² School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: mengdl@163.com.

PMID: 35597315
DOI: 10.1016/j.phytochem.2022.113240

Abstract

Six undescribed isoquinolines, including one rarely reported N-benzyl isoquinoline together with sixteen known ones were isolated from C. tomentella. Their planar structures and absolute configurations were elucidated by extensive analyses of UV, IR, NMR, HRESIMS, DP4+ probability analysis as well as ECD calculations. Biological evaluations revealed that 3,4-2H-tomentelline C (6) showed significant cytotoxicity (IC₅₀ = 7.42 μM) against the HepG2 cell line while (1'R, 2'S)-coptichine B (3) exhibited stronger antibacterial activities.

Keywords: Antibacterial; Corydalis tomentella Franch; Cytotoxicity; Isoquinoline.

MeSH terms

Alkaloids* / chemistry
Anti-Bacterial Agents / pharmacology
Corydalis* / chemistry
Isoquinolines / chemistry
Molecular Structure

Substances

Alkaloids
Anti-Bacterial Agents
Isoquinolines