Radix Ranunculi ternati: review of its chemical constituents, pharmacology, quality control and clinical applications

J Pharm Pharmacol. 2022 Jul 15;74(7):930-952. doi: 10.1093/jpp/rgac018.

Abstract

Objectives: Radix ranunculi ternati (RRT) is widely used as traditional and folk medicine distributed in China, as well as in Kyushu and Shikoku in Japan. Although RRT has a short history of use as medicine, it has a high medicinal value. This study summarizes the research progress on the chemical constituents, pharmacological activity, quality control measures and clinical applications to provide a valuable and exhaustive reference for the development and application of RRT.

Key findings: Phytochemical studies showed that this plant mainly contains glycosides, organic acids, esters, sterols, flavonoids, alkaloids and volatile oils. The pharmacological activity of RRT includes immune regulation, anti-tumour, anti-tuberculosis, antioxidant, antibacterial, hepatoprotective and anti-inflammatory effects. This plant is especially effective in the treatment of cancer, tuberculosis, thyroid and nasopharynges disorders.

Keywords: Radix Ranunculi ternati; chemical constituents; clinical application; pharmacological activity; quality control.

Publication types

  • Review

MeSH terms

  • Drugs, Chinese Herbal* / pharmacology
  • Drugs, Chinese Herbal* / therapeutic use
  • Ethnopharmacology
  • Humans
  • Phytochemicals / pharmacology
  • Plant Extracts / pharmacology
  • Plant Roots
  • Quality Control
  • Ranunculus*
  • Tuberculosis* / drug therapy

Substances

  • Drugs, Chinese Herbal
  • Phytochemicals
  • Plant Extracts