The differential expression of long interspersed nuclear elements-1 as a marker for hypomethylation in Merkel cell carcinoma

Yuko Kuriyama; Akira Shimizu; Jain Kim; Masahito Yasuda; Sei-Ichiro Motegi

doi:10.1111/ced.15265

The differential expression of long interspersed nuclear elements-1 as a marker for hypomethylation in Merkel cell carcinoma

Clin Exp Dermatol. 2022 Sep;47(9):1726-1728. doi: 10.1111/ced.15265. Epub 2022 Jul 12.

Authors

Yuko Kuriyama¹, Akira Shimizu^{1

2}, Jain Kim¹, Masahito Yasuda¹, Sei-Ichiro Motegi¹

Affiliations

¹ Department of Dermatology, Gunma University Graduate School of Medicine, Gunma, Japan.
² Department of Dermatology, Kanazawa Medical University, Ishikawa, Japan.

PMID: 35596537
DOI: 10.1111/ced.15265

Abstract

The protein long interspersed nuclear elements-1 (LINE-1) serves as a useful surrogate marker of global methylation but little is known for Merkel cell carcinoma. LINE-1 expression was found only in Merkel cell polyomavirus (MCPyV)-positive Merkel cell carcinomas but not in MCPyV-negative Merkel cell carcinomas, suggesting that epigenetic dysregulation may be associated with MCPyV expression.

Publication types

Letter

MeSH terms

Biomarkers
Carcinoma, Merkel Cell* / genetics
Carcinoma, Merkel Cell* / pathology
Humans
Merkel cell polyomavirus* / genetics
Polyomavirus Infections*
Skin Neoplasms* / pathology
Tumor Virus Infections*

Substances

Biomarkers