Autism Spectrum Disorder and Gender Dysphoria/Incongruence. A systematic Literature Review and Meta-Analysis

J Autism Dev Disord. 2023 Aug;53(8):3103-3117. doi: 10.1007/s10803-022-05517-y. Epub 2022 May 20.

Abstract

The suggested overlap between autism spectrum disorder (ASD) and gender dysphoria/incongruence (GD/GI) has been much disputed. This review showed a relationship between ASD traits and GD feelings in the general population and a high prevalence of GD/GI in ASD. Our meta-analyses revealed that the pooled estimate of the prevalence of ASD diagnoses in GD/GI people was 11% (p < .001) and the overall effect size of the difference in ASD traits between GD/GI and control people was significant (g = 0.67, p < .001). Heterogeneity was high in both meta-analyses. We demonstrated that the chances that there is not a link between ASD and GD/GI are negligible, yet the size of it needs further investigation.

Keywords: Autism spectrum disorder; Gender dysphoria; Gender identity; Literature review; Meta-analysis.

Publication types

  • Systematic Review
  • Meta-Analysis

MeSH terms

  • Autism Spectrum Disorder* / diagnosis
  • Autism Spectrum Disorder* / epidemiology
  • Gender Dysphoria* / diagnosis
  • Gender Dysphoria* / epidemiology
  • Humans
  • Prevalence