MDSCs might be "Achilles heel" for eradicating CSCs

Tao Yang; Ning Liang; Jing Li; Pan Hu; Qian Huang; Zifeng Zhao; Qian Wang; Hongxin Zhang

doi:10.1016/j.cytogfr.2022.04.006

MDSCs might be "Achilles heel" for eradicating CSCs

Cytokine Growth Factor Rev. 2022 Jun:65:39-50. doi: 10.1016/j.cytogfr.2022.04.006. Epub 2022 May 4.

Authors

Tao Yang¹, Ning Liang², Jing Li³, Pan Hu⁴, Qian Huang⁵, Zifeng Zhao¹, Qian Wang⁶, Hongxin Zhang⁷

Affiliations

¹ Department of Pain Treatment, Tangdu Hospital, Air Force Military Medical University, Xi'an 710032, China.
² Department of General Surgery, The 75th Group Army Hospital, Dali 671000, China.
³ Department of Stomatology, Shaanxi Provincial Hospital, Xi'an, Shaanxi 710038, China.
⁴ Department of Anesthesiology, the 920 Hospital of Joint Logistic Support Force of Chinese PLA, Kunming, Yunnan, China.
⁵ Department of Gynaecology and Obstetrics, The 75th Group Army Hospital, Dali 671000, China.
⁶ Department of Anorectal Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. Electronic address: 1211072068@qq.com.
⁷ Department of Pain Treatment, Tangdu Hospital, Air Force Military Medical University, Xi'an 710032, China; Department of Intervention Therapy, The Second Affiliated Hospital, Shaanxi University of Traditional Chinese Medicine, Xianyang 712046, China. Electronic address: zhhxtdjr@163.com.

PMID: 35595600
DOI: 10.1016/j.cytogfr.2022.04.006

Abstract

During tumor initiation and progression, the complicated role of immune cells in the tumor immune microenvironment remains a concern. Myeloid-derived suppressor cells (MDSCs) are a group of immune cells that originate from the bone marrow and have immunosuppressive potency in various diseases, including cancer. In recent years, the key role of cancer stemness has received increasing attention in cancer development and therapy. Several studies have demonstrated the important regulatory relationship between MDSCs and cancer stem cells (CSCs). However, there is still no clear understanding regarding the complex interacting regulation of tumor malignancy, and current research progress is limited. In this review, we summarize the complicated role of MDSCs in the modulation of cancer stemness, evaluate the mechanism of the relationship between CSCs and MDSCs, and discuss potential strategies for eradicating CSCs with respect to MDSCs.

Keywords: Cancer plasticity; Cancer stem cells; Cytokines; MDSCs; Tumor progression.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Myeloid-Derived Suppressor Cells*
Neoplasms*
Neoplastic Stem Cells
Tumor Microenvironment