Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Paul A Cobine; Donita C Brady

doi:10.1016/j.molcel.2022.05.001

Cuproptosis: Cellular and molecular mechanisms underlying copper-induced cell death

Mol Cell. 2022 May 19;82(10):1786-1787. doi: 10.1016/j.molcel.2022.05.001.

Authors

Paul A Cobine¹, Donita C Brady²

Affiliations

¹ The Department of Biological Sciences, Auburn University, Auburn, AL 36849, USA. Electronic address: pac0006@auburn.edu.
² Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bradyd@pennmedicine.upenn.edu.

PMID: 35594843
DOI: 10.1016/j.molcel.2022.05.001

Abstract

Tsvetkov et al. (2022) discovered a new form of cell death triggered by targeted accumulation of Cu in mitochondria that drives lipoylated TCA cycle enzyme aggregation via direct Cu binding.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Apoptosis*
Cell Death
Copper* / metabolism
Lipoylation
Mitochondria* / metabolism

Substances

Copper