Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Hiroshi Tateishi; Daiki Setoyama; Takahiro A Kato; Dongchon Kang; Jun Matsushima; Kojiro Nogami; Seiji Mawatari; Ryohei Kojima; Yuka Fujii; Yuta Sakemura; Takumi Shiraishi; Yoshiomi Imamura; Toshihiko Maekawa; Toyoko Asami; Yoshito Mizoguchi; Akira Monji

doi:10.1016/j.psychres.2022.114636

Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study

Psychiatry Res. 2022 Jul:313:114636. doi: 10.1016/j.psychres.2022.114636. Epub 2022 May 14.

Authors

Affiliations

¹ Department of Psychiatry, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, 849-8501, Japan. Electronic address: tateishh@cc.saga-u.ac.jp.
² Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi Higashi-ku 3-1-1, Fukuoka, 812-8582, Japan.
³ Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi Higashi-ku 3-1-1, Fukuoka, 812-8582, Japan. Electronic address: takahiro@npsych.med.kyushu-u.ac.jp.
⁴ Department of Psychiatry, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, 849-8501, Japan.
⁵ Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi Higashi-ku 3-1-1, Fukuoka, 812-8582, Japan.
⁶ Department of Rehabilitation Medicine, Saga University Hospital, Nabeshima 5-1-1, Saga, 849-8501, Japan.

PMID: 35594657
DOI: 10.1016/j.psychres.2022.114636

Abstract

Repetitive transcranial magnetic stimulation (rTMS) improves depressive symptoms in treatment-resistant depression (TRD). This study aimed to analyze changes in cerebrospinal fluid (CSF) metabolites in patients with TRD after rTMS. Five patients with TRD were enrolled in a high frequency (10-Hz) rTMS study. The concentration of 72 CSF metabolites were measured at baseline and at the end of the 6-week rTMS treatment. rTMS significantly increased CSF niacinamide, kynurenine, and creatinine levels and significantly decreased CSF cystine levels, but not the levels of the other 68 CSF metabolites. This is the first CSF metabolomics study on patients with TRD who underwent rTMS.

Keywords: Cerebrospinal fluid; Repetitive transcranial magnetic stimulation; Treatment-resistant depression.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Depression / therapy
Depressive Disorder, Treatment-Resistant* / therapy
Humans
Kynurenine
Pilot Projects
Prefrontal Cortex / physiology
Transcranial Magnetic Stimulation*
Treatment Outcome

Substances

Kynurenine