Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP

Qiang Zhang; Paul Wilson; Athina Anastasaki; Ronan McHale; David M Haddleton

doi:10.1021/mz5001724

Synthesis and Aggregation of Double Hydrophilic Diblock Glycopolymers via Aqueous SET-LRP

ACS Macro Lett. 2014 May 20;3(5):491-495. doi: 10.1021/mz5001724. Epub 2014 May 9.

Authors

Qiang Zhang¹, Paul Wilson^{1

2}, Athina Anastasaki¹, Ronan McHale¹, David M Haddleton^{1

2}

Affiliations

¹ Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.
² Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia.

PMID: 35590789
DOI: 10.1021/mz5001724

Abstract

A chemically unprotected mannose-containing acrylate (ManA) monomer was synthesized and polymerized by Cu(0)-mediated radical polymerization in water (SET-LRP). One-pot block copolymerization was achieved upon addition of a solution of N-isopropylacrylamide (NIPAm) or diethylene glycol ethyl ether acrylate (DEGEEA) forming thermoresponsive double hydrophilic diblock glycopolymers which revealed self-assembly properties in aqueous solution forming well-defined, sugar-decorated nanoparticles.