Various types of electrochemical biosensors for leukemia detection and therapeutic approaches

Supat Chupradit; Mahyuddin Km Nasution; Heshu Sulaiman Rahman; Wanich Suksatan; Abduladheem Turki Jalil; Walid Kamal Abdelbasset; Dmitry Bokov; Alexander Markov; Irina N Fardeeva; Gunawan Widjaja; Mohammed Nader Shalaby; Marwan Mahmood Saleh; Yasser Fakri Mustafa; A Surendar; Ramtin Bidares

doi:10.1016/j.ab.2022.114736

Various types of electrochemical biosensors for leukemia detection and therapeutic approaches

Anal Biochem. 2022 Oct 1:654:114736. doi: 10.1016/j.ab.2022.114736. Epub 2022 May 17.

Authors

Supat Chupradit¹, Mahyuddin Km Nasution², Heshu Sulaiman Rahman³, Wanich Suksatan⁴, Abduladheem Turki Jalil⁵, Walid Kamal Abdelbasset⁶, Dmitry Bokov⁷, Alexander Markov⁸, Irina N Fardeeva⁹, Gunawan Widjaja¹⁰, Mohammed Nader Shalaby¹¹, Marwan Mahmood Saleh¹², Yasser Fakri Mustafa¹³, A Surendar¹⁴, Ramtin Bidares¹⁵

Affiliations

¹ Department of Occupational Therapy, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai, 50200, Thailand.
² Ethical Clearance Committee, Universitas Sumatera Utara, Medan, Indonesia. Electronic address: mahyuddin@usu.ac.id.
³ Department of Medical Laboratory Sciences, Komar University of Science and Technology, Chaq-Chaq Qularaise, Sulaimaniyah, Iraq; College of Medicine, University of Sulaimani, Sulaimaniyah, Iraq.
⁴ Faculty of Nursing, HRH Princess Chulabhorn College of Medical Science, Chulabhorn Royal Academy, Bangkok, 10210, Thailand.
⁵ Faculty of Biology and Ecology, Yanka Kupala State University of Grodno, 230023, Grodno, Belarus; College of Technical Engineering, The Islamic University, Najaf, Iraq. Electronic address: abedalazeem799@gmail.com.
⁶ Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
⁷ Institute of Pharmacy, Sechenov First Moscow State Medical University, Russian Federation; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, 2/14 Ustyinsky pr., Moscow, 109240, Russian Federation.
⁸ Tyumen State Medical University, Tyumen, Russian Federation.
⁹ Kazan Federal University, Russia.
¹⁰ Universitas Krisnadwipayana, Jatiwaringin, Indonesia.
¹¹ Biological Sciences and Sports Health Department, Faculty of Physical Education, Suez Canal University, Egypt.
¹² Department of Biophysics, College of Applied Sciences, University of Anbar, Iraq.
¹³ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, 41001, Iraq.
¹⁴ Department of Pharmacology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
¹⁵ Department of Anatomy, Histology Forensic Medicine, Sapienza University of Rome, Rome, Italy.

PMID: 35588855
DOI: 10.1016/j.ab.2022.114736

Abstract

Leukemia often initiates following dysfunctions in hematopoietic stem cells lineages. Various types of leukemia, including acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), acute promyelocytic leukemia (APL), and human T-cell leukemia/lymphoma virus type 1 (HTLV-1) can thus call for different diagnosis and treatment options. One of the most important subjects in leukemia is the early detection of the disease for effective therapeutic purposes. In this respect, biosensors detecting the molecules of deoxyribonucleic acid (DNA) as analytes are called genosensors or DNA biosensors. Electrochemical sensors, as the most significant approach, also involve reacting of chemical solutions with sensors to generate electrical signals proportional to analyte concentrations. Biosensors can further help detect cancer cells in the early stages of the disease. Moreover, electrochemical biosensors, developed based on various nanomaterials (NMs), can increase sensitivity to the detection of leukemia-related genes, e.g., BCR/ABL as a fusion gene and promyelocytic leukemia/retinoic acid receptor alpha (PML/RARα). Therefore, the present review reflects on previous studies recruiting different NMs for leukemia detection.

Keywords: Biosensor; Electrochemical; Leukemia; Nanomaterial.

Publication types

Review

MeSH terms

Biosensing Techniques*
DNA
Hematopoietic Stem Cells
Humans
Leukemia, Promyelocytic, Acute* / diagnosis
Leukemia, Promyelocytic, Acute* / drug therapy
Leukemia, Promyelocytic, Acute* / genetics

Substances

DNA