Efficacy of inhaled CPZEN-45 in treating tuberculosis in the guinea pig

Tuberculosis (Edinb). 2022 Jul:135:102207. doi: 10.1016/j.tube.2022.102207. Epub 2022 Apr 5.

Authors

Ellen F Young¹, Phillip G Durham², Ellen F Perkowski¹, Seidu Malik¹, Anthony J Hickey³, Miriam Braunstein⁴

Affiliations

¹ Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA.
² RTI International, Research Triangle Park, NC, 27709, USA.
³ RTI International, Research Triangle Park, NC, 27709, USA. Electronic address: ahickey@rti.org.
⁴ Department of Microbiology and Immunology, School of Medicine, University of North Carolina at Chapel Hill, NC, 27599, USA. Electronic address: braunste@med.unc.edu.

PMID: 35588549
DOI: 10.1016/j.tube.2022.102207

No abstract available

Keywords: Aerosol; Antibiotic; CPZEN-45; Guinea pig; Tuberculosis.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Antitubercular Agents / therapeutic use
Azepines
Disease Models, Animal
Guinea Pigs
Lung
Mycobacterium tuberculosis*
Tuberculosis, Pulmonary* / drug therapy

Substances

Antitubercular Agents
Azepines
CPZEN-45

Grants and funding

R01 AI091882/AI/NIAID NIH HHS/United States