This article investigates the resilient proportional-integral observer (PIO) problem for Markov switching memristive neural networks (MSMNNs) with randomly occurring sensor saturation within a finite-time interval. The Markov switching of memristive neural networks is regulated by a higher level deterministic switching signal, whose transition probabilities are piecewise time-varying and can be depicted by the average dwell-time strategy. Meanwhile, a Bernoulli stochastic process associated with an uncertain packet arriving rate is adopted to describe the randomly occurring sensor saturation. The aim is to design a resilient PIO such that the augmented dynamic has the property of stochastic finite-time boundedness while meeting the desired performance index. By applying the Lyapunov method and the average dwell-time scheme, sufficient criteria are established for MSMNNs, and a unified design method is presented for the existence of the PIO. Lastly, the attained theoretical results are validated via a numerical simulation.