The fluid flow with chemical reaction is one of well-known research areas in the field of computational fluid dynamic. It is potentially useful in the modelling of flow on a nuclear reactor. Motivated by the implementation of the flow in the industrial application, the aim of this study is to explore the time-dependent squeeze flow of magnetohydrodynamic Jeffrey fluid over permeable medium in the influences of Soret and Dufour, heat source/sink and chemical reaction. The presence of joule heating, joule dissipation and radiative heat transfer are analyzed. The flow is induced due to compress of two surfaces. Conversion of partial differential equations (PDEs) into ordinary differential equations (ODEs) is accomplished by imposing similarity variables. Then, the governing equations are resolved using Keller-box approach. The present outcomes are compared with previously outcomes in the literature to validate the precision of present outcomes. Both outcomes are shown in close agreement. The tabular and graphical results demonstrate that wall shear stress and velocity profile accelerate with the surfaces moving towards one another. Moreover, the concentration, temperature and velocity profiles decreasing for the increment of Hartmann numbers and Jeffrey fluid parameters. The impacts of heat generation/absorption, joule dissipation and Dufour numbers enhance the heat transfer rate and temperature profile. In contrast, the temperature profile drops and the heat transfer rate boosts when thermal radiation increases. The concentration profile decelerates, and the mass transfer rate elevates with raise in Soret number. Also, the mass transfer rate rises for destructive chemical reaction and contrary result is noted for convective chemical reaction.