The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Dongshuai Qu; Hongjie Hu; Shuaitao Lian; Wenjing Sun; Hongbin Si

doi:10.3389/fvets.2022.870042

The Protective Effects of Three Polysaccharides From Abrus cantoniensis Against Cyclophosphamide-Induced Immunosuppression and Oxidative Damage

Front Vet Sci. 2022 May 2:9:870042. doi: 10.3389/fvets.2022.870042. eCollection 2022.

Authors

Dongshuai Qu¹, Hongjie Hu¹, Shuaitao Lian¹, Wenjing Sun², Hongbin Si¹

Affiliations

¹ State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Animal Science and Technology, Guangxi University, Nanning, China.
² Guangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, College of Biology & Pharmacy, Yulin Normal University, Yulin, China.

Abstract

This study was designed to systematically elucidate the immunomodulatory and antioxidant effects of three polysaccharide fractions (ACP₆₀, ACP₈₀, and ACP_t2) from Abrus cantoniensis on cyclophosphamide (CTX)-induced immunosuppressive mice. The experimental mice were divided into 12 groups, then modeled and administrated with different doses of three polysaccharides (50, 150, 300 mg/kg/day) by gavage. The results showed that ACP could markedly recover the CTX-induced decline in immune organ and hemocytes indexes and promote proliferation of splenocytes, earlap swelling rate, secretion of cytokines (TNF-α, IFN-γ, IL-1β, IL-6), and immunoglobulin (Ig-M and Ig-G). Additionally, ACP improved the enzymatic activities of T-SOD and GSH-PX greatly, while the level of MDA was significantly decreased in the liver. In particular, ACP_t2 had higher immunomodulatory and antioxidant activities than ACP₆₀ and ACP₈₀. Based on the present findings, ACP could be utilized as an efficacious candidate for immunomodulators and antioxidants, which provide a new application prospect in the food and pharmaceutical industries.

Keywords: Abrus cantoniensis; antioxidation; cyclophosphamide-induced immunosuppression (CTX-induced immunosuppression); immunoregulation; natural polysaccharides.