Peripheral neuropathy in sarcoidosis

Jinny Tavee

doi:10.1016/j.jneuroim.2022.577864

Peripheral neuropathy in sarcoidosis

J Neuroimmunol. 2022 Jul 15:368:577864. doi: 10.1016/j.jneuroim.2022.577864. Epub 2022 Apr 9.

Author

Jinny Tavee¹

Affiliation

¹ Division of Neurology, National Jewish Health, Department of Medicine, 1400 Jackson Street, Denver, CO 80209, USA. Electronic address: taveej@njhealth.org.

PMID: 35585009
DOI: 10.1016/j.jneuroim.2022.577864

Abstract

Peripheral nerve disorders in sarcoidosis consist of granulomatous neuropathy and non-granulomatous small fiber neuropathy (SFN), which differ in their underlying pathology, diagnostic methods and treatment. While granulomatous nerve involvement is rare in sarcoidosis, SFN is reported in over 40% of systemic cases. Distal symmetric polyneuropathy and asymmetric polyradiculoneuropathy are the most common presentations of granulomatous neuropathy, which typically responds to corticosteroids. In contrast, SFN is often manifested as non-length dependent pain and paresthesias that may improve with intravenous immune globulin or infliximab. Early recognition and treatment of sarcoidosis neuropathy can lead to improved outcomes and patient quality of life.

Keywords: Granulomatous neuropathy; IVIG; Sarcoidosis neuropathy; Sarcoidosis small fiber neuropathy.

Publication types

Review

MeSH terms

Humans
Pain
Peripheral Nervous System Diseases* / diagnosis
Quality of Life
Sarcoidosis* / complications
Sarcoidosis* / diagnosis
Small Fiber Neuropathy* / diagnosis
Small Fiber Neuropathy* / pathology
Small Fiber Neuropathy* / therapy