Too much water drowned the miller: Akkermansia determines immunotherapy responses

Le Li; Florencia McAllister

doi:10.1016/j.xcrm.2022.100642

Too much water drowned the miller: Akkermansia determines immunotherapy responses

Cell Rep Med. 2022 May 17;3(5):100642. doi: 10.1016/j.xcrm.2022.100642.

Authors

Le Li¹, Florencia McAllister²

Affiliations

¹ Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, TX 77030, USA.
² Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, TX 77030, USA; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, TX 77030, USA; Department of Immunology. The University of Texas MD Anderson Cancer Center, TX 77030, USA. Electronic address: fmcallister@mdanderson.org.

Abstract

Derosa et al.¹ demonstrated that intestinal Akkermansia muciniphila predicts vigorous response to immunotherapy in non-small-cell lung cancer. Baseline level of this microbe has better value than PD-L1 expression and represents a unique approach for stratifying patients that can benefit from immunotherapy.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment

MeSH terms

Akkermansia
Carcinoma, Non-Small-Cell Lung* / therapy
Humans
Immunologic Factors
Immunotherapy / adverse effects
Lung Neoplasms* / therapy

Substances

Immunologic Factors

Grants and funding

R37 CA237384/CA/NCI NIH HHS/United States